What is micro dosing?

This article is for informative purposes only

Microdosing Psilocybin

The act of microdosing is when a user consumes a sub-perceptual dose of a psychoactive compound. Advocates of microdosing believe consuming an extremely small dose of a psychedelic substance brings some of the positive effects of the substance while still allowing the user to remain fully functional to carry on with all of the activities of a standard day. Typical dosages are somewhere around a tenth of the amount of a standard dose.

History of Microdosing

When it comes to microdosing, there is very little history in regards to scientific studies surrounding this method of consumption. The history behind microdosing is very unclear, but it is known that Albert Hofmann, the chemist who discovered LSD, began microdosing in the later parts of his life during the 1990s. Prior to the 1966 prohibition on psychedelic research, no formal studies were conducted on microdosing. There has been some progress made in starting the process that will allow researchers to study microdosing in a formal setting. Some scientists are trying to make their case through congregating user reports while others are doing initial clinical trials to determine the safety of studying microdosing.

Why do People Microdose? 

People try microdosing for a variety of reasons. Some microdose to alleviate the symptoms of their mental illnesses such as anxiety and depression, while others are trying to increase their productivity and creative problem-solving abilities.

What is Considered a Microdose of Psilocybin?

A microdose is considered a sub-perceptual dose, meaning it does not produce any acute effects. When a user microdoses they will not feel any effects kicking in or feel as though they are “high.” Most users microdose psilocybin to help alleviate their symptoms of depression and anxiety, and improve both convergent and divergent thinking performance. A study from 2018 showed preliminary results that back up the claims surrounding convergent and divergent thinking. Typical microdoses are a tenth of a normal dose. Dr. Fadiman, a strong advocate for microdosing and psychedelic research, recommends a dosage of 0.2g of dried mushroom once every three or four days.

What the Community Says about Microdosing Psilocybin

The psychedelic community strongly believes microdosing psilocybin should be further studied for its potential therapeutic benefits. A wide range of reports that exist that include anecdotal reports of individuals regularly microdosing with psilocybin.

One of these reports involved a person suffering from Bipolar II and PTSD looking for a solution to their seasonal depression. After trying a wide range of medications and therapies, they eventually tried microdosing with a full understanding it could increase their levels of mania. They found taking 0.2 grams every fourth day highly increased mania, so they cut back the regularity and dosage to 0.15 grams every other week. This new schedule helped them better manage their seasonal depression even going as far as stating, “it was the first winter I’ve ever had where I wasn’t depressed.” Another user suffering from depression reported that they “felt more capable, emotionally resilient, faster in mental/emotional recovery, and a much-improved ability to choose other actions.”

What Scientists Say about Microdosing Psilocybin

As of November 2019, there are very few rigorous, scientific studies on the effects of microdosing psilocybin. This is largely due to the regulations surrounding the study of psychedelic substances. However, scientists have collected anecdotal evidence to support their desire to further study the potential benefits and risks of microdosing. One study interviewed 21 individuals microdosing psilocybin mushrooms on a regular basis. This study found that the users reported “mostly positive consequences” with effects including an improved mood, cognition, and creativity.

Dr. James Fadiman is another scientist collecting anecdotal information to show why microdosing should be further studied under rigorous scientific standards. He is actively collecting reports from anyone who has microdosed in the past or is currently doing it.

What the Critics say about Microdosing Psilocybin

There has been widespread growth in the attention that microdosing has received in recent years. This has led to critics pointing out potential downsides as the practice becomes more and more common. A large amount of these criticisms base their claims on a study conducted on microdosing DMT with rats. The study found that microdoses of DMT affected the metabolism of male rats resulting in weight gain. It also found that female rats had developed neuronal atrophy. The other common criticism of microdosing psilocybin is its potential to cause an upset stomach which is a common side effect of psilocybin mushrooms.

Where do I Buy Psilocybin to Microdose?

While psilocybin mushrooms are subject to the Controlled Substances Act in the United States and the United Nations Convention on Psychotropic Substances which requires its members to prohibit psilocybin, spores of psilocybin mushrooms are legal in many areas of the world. These spores can then be used to grow your own psilocybin mushrooms. However, once these mushrooms have grown, they become an illegal substance.

What to Know Before Microdosing Psilocybin 

One of the most important aspects of microdosing is ensuring a consistent dosage. Dosage refers to the dose of the substance as well as the time-frequency and duration that the doses are taken. A microdose is such a small amount that it is easy to accidentally consume a larger dose than expected. Psilocybin mushrooms make this even more difficult due to the varying strengths of the different species and individual mushrooms. One example of this can be seen in the differences in potency between the cap and stem of psilocybin mushrooms. A study analyzing psilocybin mushrooms in Japan found that the P. cubensis had a maximum potency of 1.27% in the stem and 1.35% in the cap. This study also showed whole mushrooms had a potency ranging from 0.37% to 1.30%.

Furthermore, as Dr. James Faidman and user reports suggest the frequency with which you microdose plays a role in its effects. Dr. Faidman prescribes a microdose every third day, but individuals have experimented with different dosages as well.

Common Effects when Microdosing Psilocybin 

Common effects of microdosing psilocybin include:

  • Improvements in mood, cognition, and creativity.

How to Microdose Psilocybin  

In the psychedelic community, microdosing psilocybin means consuming a very small dose of psilocybin mushrooms every third or fourth day. Typical doses range from 0.10 grams to 0.25 grams of dried P. cubensis mushrooms. Most users will pulverize the mushrooms into a powder, weigh out doses, then store those doses in size 00 capsules for later use.

Paul Stamets created a unique microdosing technique he calls “stacking.” It involves a combination of niacin, Lions Mane, and P. cubensis. This method combines approximately 0.1-1 gram of P. cubensis, 5-20 grams of Lions Mane, and 101-200 milligrams of niacin. His belief is the niacin enhances the effects of the psilocybin while reducing the psychedelic experience.

How Psilocybin Works inside the Body

Psilocybin is a serotonergic substance meaning it acts on the serotonin, or 5-hydroxytryptamine, receptors in the central and peripheral nervous system. The primary receptors it acts upon are the 5-HT2B and 5-HT2C receptors. It also activates the 5-HT2A receptors with slightly lower activity. The activity at these receptors causes an increased concentration of dopamine at the basal ganglia. This is responsible for the euphoric and psychedelic effects of psilocybin.

Small Doses

Small doses of psilocybin, referred to as a “microdose,” do not produce any acute effects, but rather a psychological and social benefit from regularly consuming microdoses. These effects include increases in:

  • Alleviated symptoms of depression and anxiety
  • Enhanced productivity
  • Improvements in overall well-being
  • Enhancements in convergent and divergent thinking

Large doses

When consumed in large doses, psilocybin produces a profound psychedelic effect involving:

  • Closed and open eye visuals
  • Dilated pupils
  • Reduced appetite
  • Euphoria
  • Heightened emotions
  • An altered sense of reality.

Common Interactions when Microdosing Psilocybin 

Psilocybin, along with most other psychedelics, causes vasoconstriction. This means mixing it with other vasoconstrictors can cause unpleasant and potentially dangerous effects. Mixing psilocybin with any MAOIs can enhance its potency which could cause a microdose to produce stronger effects than expected. Alcohol mixed with psilocybin mushrooms can place unnecessary stress on the liver since they are both metabolized by it.

Reality Sandwich Guide to Drug Combinations 1 1

Safety Concerns

The primary safety concern with microdosing psilocybin is alterations in heart rate. Using psilocybin with a pre-existing heart condition can cause tachycardia or bradycardia.

Psilocybin is a controlled substance in most of the modern world. The United States listed it as a Schedule I controlled substance under the Controlled Substances Act of 1970. However, Denver, Colorado decriminalized psilocybin mushrooms in May of 2019. The United Nations Convention on Psychotropic Substances also lists psilocybin, which requires all members of the UN to prohibit it.  However, psilocybin mushrooms are legal in Brazil and Jamaica. Psilocybin truffles are legal in the Netherlands. The Virgin Islands prohibit the sale and transport of psilocybin mushrooms, but possession and personal use is legal.


Content from https://realitysandwich.com/microdosing-psilocybin/